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Université de Bordeaux
FHU SMART Small Artery Disease transdisciplinary project
Cluster of excellence
 

Prof. Stéphanie Debette, Coordinator

Prof. Stéphanie Debette, Coordinator© Bordeaux University

Stéphanie Debette is Professor of Epidemiology at University of Bordeaux. She is currently the Director of the Bordeaux Population Health research center (University of Bordeaux – Inserm U1219). She is also practicing neurologist at the neurology Memory Clinic in Bordeaux University Hospital. she co-leads the ELEANOR team on  molecular epidemiology of vascular and brain disorders. Her research focuses on the genetic and environmental determinants of stroke, MRI markers of brain aging, small vessel disease, and cognition.

 

Summary CV

Stéphanie Debette is PI on several grants exploring environmental and genetic determinants of brain aging, especially vascular brain aging (ERC SEGWAY, ANR, JPND BRIDGET, IdEx). She is a partner on the H2020 PRESTIGE-AF project on the prevention of stroke in intracerebral haemorrhage survivors with atrial fibrillation, member of the board of directors of the world stroke organization, and in 2017-2018 she held a visiting professor position at Kyoto University Center for Genomic Medicine. She co-authored >250 publications, including first/last author papers in Nature, Nature Genetics, Lancet Neurology, BMJ, Circulation (H-Index WOS: 37). As ex-chair and member of the International Stroke Genetics Consortium (ISGC) and member of the research steering committee of the CHARGE consortium (cohorts for heart and aging research in genomic epidemiology), she has extensive international collaborations. She has organized and coordinated expert panels in the context of dissections (leading to publications in Nat Genet and Lancet Neurol). Also, since 2015 she (co-)organizes a unique annual summer school on neuroepidemiology in the omics era, Neurepiomics, held in Bordeaux, Boston, and Kyoto, with international experts in the field. 

She was also Vice-President in charge of external relations at the University of Bordeaux (2018-22) and was the inaugural chair of the ENLIGHT European University Alliance board of directors (2019-22).

She is also the founder of the Music for the Brain philanthropic initiative. 

 

List of the five major selected peer-reviewed publications


• Mishra A., Malik R., Hachiya T, […] Milani L, Kamatani Y, Dichgans M* & Debette S*. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. 2022 Sep 30.

https://doi.org/10.1038/s41586-022-05165-3


• Sargurupremraj M, Suzuki H, […], Matthews P, Fornage M, Debette S. Cerebral small vessel diseasegenomics and its implications across the lifespan. Nat Commun. 2020 Dec 8 :11(1) :6285.

https://doi: 10.1038/s41467-020-19111-2.


• Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS. Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: Systematic Review & Meta-analysis. JAMA Neurol. 2019;76:81-94. 

https://doi: 10.1001/jamaneurol.2018.3122.



• Malik R, Chauhan G, Traylor M, Sargurupremraj M, […], Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S*, Dichgans M* *co-corresponding authors. Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet. 2018;50:524-537. https://doi: 10.1038/s41588-018-0058-3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830


• Chauhan G, Arnold CR, […], Debette S. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol, 2016;15:695-707.

https://doi: 10.1016/S1474-4422(16)00102-2

 

Selected publications

>250 articles in PubMed, H-index: 61 WOS 


• Mishra A, Duplaà C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilhão NR, […], Couffinhal T, Debette S, Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate, Brain, Volume 145, Issue 6, June 2022, Pages 1992–2007, https://doi.org/10.1093/brain/awab432

• Wardlaw JM, Debette S, Jokinen H, et al. ESO Guideline on covert cerebral small vessel disease. European Stroke Journal. 2021;6(2):CXI-CLXII. https://doi:10.1177/23969873211012132

• Soumaré A, Beguedou N, Laurent A, Brochet B, Bordes C, Mournet S, Mellet E, Pereira E, Pollet C, Lachaize M, Mougin M, Tsuchida A, Loiseau H, Tourdias T, Tzourio C, Mazoyer B and Debette S. Prevalence, severity, and clinical management of brain incidental findings in healthy young adults: MRi-Share cross-sectional study. Front. Neurol.20 May 2021. 12:675244. https://doi.org/10.3389/fneur.2021.675244

• Mishra A, Chauhan G, Violleau MH, Soumare A, Vojinovic D, Jian X, Bis J, Li S, Saba Y, Yang Q, Bartz T, Hofer E, Zhu Y, Mazoyer B, Lathrop M, Schmidt H, Van Duijn C, Ikram MA, Longstreth WT, Fornage M, Seshadri S, Joutel A, Tzourio C, Debette S. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older community persons: an exome sequencing study. BRAIN, 2019 Apr 1;142(4):1009-1023. https://doi: 10.1093/brain/awz024.

• Duperron MG, Tzourio C, Sargurupremraj M, Mazoyer B, Soumaré A, Schilling S, Amouyel P, Chauhan G, Zhu YC, Debette S. Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable. Stroke. 2018 Feb;49(2):282-287. doi: 10.1161/STROKEAHA.117.019309. Epub 2018 Jan 8. PMID:29311265


Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS. Clinical significance of MRI-markers of vascular brain injury. A systematic review and meta-analysis. JAMA Neurol. 2018 Oct 22. doi: 10.1001/jamaneurol.2018.3122.PMID:30422209

• Woo D, Anderson CD, Maguire J, Fornage M, Lee JM, Seshadri S, Markus HS, Majersik JJ, Jimenez-Conde J, Crawford K, Lindgren AG, Debette S. Top research priorities for stroke genetics. Lancet Neurol. 2018 Aug;17(8):663-665. doi.org/10.1016/S1474-4422(18)30243-6. PMID: 30033056


• Duperron MG, Tzourio C, Sargurupremraj M, Mazoyer B, Soumaré A, Schilling S, Amouyel P, Chauhan G, Zhu YC, Debette S. Burden of Dilated Perivascular Spaces, an Emerging Marker of Cerebral Small Vessel Disease, Is Highly Heritable. Stroke. 2018; 49:282-287. https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.117.019309


• Schilling S, Tzourio C, Soumaré A, Kaffashian S, Dartigues JF, Ancelin ML, Samieri C, Dufouil C, Debette S. Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C- Study: A longitudinal, population-based prospective cohort study. Plos Med 2017 14(3):e1002265. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369688/


• Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, […], Van der Wee NJ, Van Duijn CM, […], DeCarli C, Schmidt H, Martin NG, De Craen AJ, Wright MJ, Launer LJ*, Schumann G*, Fornage M*, Franke B*, Debette S*, Medland SE*, Ikram MA*, Thompson PM*. * starred last authors Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016; 19:1569-1582. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227112/


Debette S, Ibrahim Verbaas CA, Bressler J, […], Tzourio C, Papassotiropoulos A, Bennett DA, Ikram MA, Deary IJ, van Duijn CM, Launer L, Fitzpatrick AL, Seshadri S, Mosley Jr TH, for the CHARGE Consortium. Genetic variants in immune and ubiquitin pathways associate with verbal memory. Biol Psy. 2015;77:749-63.PMC4513651



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